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executive dysfunction, which can include problems with planning, cognitive flexibility, abstract thinking, rule acquisition, initiating appropriate actions and inhibiting inappropriate actions, and selecting relevant sensoiy information, fluctuations in attention and slowed cognitive speed, memory (especially in recalling learned information), visuospatial difficulties e.g

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Based on an average daily water consumption of 4 ml, the estimated daily dose of GGsTop for a 25 g mouse was 10 mg kg 1 per day (equivalent to 5 mg kg 1 twice a day i.p

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